| Atributo | Detalles |
|---|---|
| Species | Mouse |
| Assay Type | Solid Phase Sandwich ELISA |
| Sensitivity | 8 pg/mL |
| Detection Range | 15.6-1000 pg/ml |
| Assay Length | 3.5h |
| Tipo de ejemplo | Suero; Plasma; Cell culture supernatant |
| Long Name | NLR family pyrin domain containing 3 |
| Sinónimos | AGTAVPRL; AII; AII/AVP; Angiotensin/vasopressin receptor AII/AVP-like; AVP; C1orf7; Caterpiller protein 1.1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1 proteína; Cold autoinflammatory syndrome 1; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; Leucine-rich repeat-, and PYD-containing protein 3; Muckle-Wells syndrome; MWS; NACHT; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NALP3; NLR family, pyrin domain containing 3; NLRP3; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3; PYPAF1; PYRIN-containing APAF1-like protein 1 |
| Background | NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 y 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78% y 93% aa identity with human and rat NLRP3, respectivamente. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 y 7, or LRR4-9. |
Solarbio Mouse NLRP3/NALP3/CIAS1/PYPAF Elisa Kit
$276.00 – $475.00
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| tamaño | 48t, 96t |
|---|---|
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