Solarbio Mouse NLRP3/NALP3/CIAS1/PYPAF Elisa Kit

Name: Solarbio Mouse NLRP3/NALP3/CIAS1/PYPAF Elisa Kit
SKU: 5668
Availability: InStock

$276.00 – $475.00

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Deskripsi

Atribut	Detail
Species	Mouse
Assay Type	Solid Phase Sandwich ELISA
Sensitivity	8 pg/mL
Detection Range	15.6-1000 pg/ml
Assay Length	3.5H
Sample Type	Serum; Plasma; Cell culture supernatant
Long Name	NLR family pyrin domain containing 3
Sinonim	AGTAVPRL; AII; AII/AVP; Angiotensin/vasopressin receptor AII/AVP-like; AVP; C1orf7; Caterpiller protein 1.1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cold autoinflammatory syndrome 1; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; Leucine-rich repeat-, and PYD-containing protein 3; Muckle-Wells syndrome; MWS; NACHT; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NALP3; NLR family, pyrin domain containing 3; NLRP3; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3; PYPAF1; PYRIN-containing APAF1-like protein 1
Background	NLRP3, also known as NALP3, CIAS1, PYPAF or Cryopyrin, is a cytosolic ~120 kDa member of the NLRP family of proteins expressed in leukocytes, especially neutrophils. As a component of the inflammasome, NLRP3 activates caspases 1 Dan 5. Defects in NLRP3 may cause FCAS1, CINCA, or Muckle-Wells autoinflammatory syndromes. Mouse NLRP3 contains an N-terminal Pyrin domain (aa 1-91) followed by a Nacht region (aa 216-532), and seven LRRs (aa 739-988). Within the sequence used as an immunogen, mouse NLRP3 shares 78% Dan 93% aa identity with human and rat NLRP3, masing-masing. Alternate splicing of mouse NLRP3 generates additional isoforms that lack either LRR2 and 3, LRR 6 Dan 7, or LRR4-9.