사양
- 100mg Powder
| 제품정보 | |
|---|---|
| 카스 | 1119-34-2 |
| Chinese Name | L-精氨酸盐酸盐 |
| 영어 이름 | L-Arginine Hydrochloride |
| 동의어 |
|
| 분자식 | C6H14N4O2·HCl |
| 분자 무게 | 210.66 |
| 명세서 | 10mM*1mL in Water; 100mg |
| 용해도 | Soluble in Water ≥10mg/mL |
| 보관 조건 | 가루: 2-8℃, 2 연령; In solution: -20℃, 6 개월; -80℃, 1 년도 |
| 청정 | HPLC≥98% |
| 모습 | White to off-white Solid |
| 단위 | 병 |
| EC | EINECS 214-275-1 |
| MDL | MFCD00064550 |
| SMILES | NC@@HC(O)=O.[H]Cl |
| InChIKey | KWTQSFXGGICVPE-WCCKRBBISA-N |
| InChI | InChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1 |
| PubChem CID | 66250 |
| 대상 | Others |
| Pathway | Others |
| Background Information | Reported to be an effective vasodilator used to induce experimental acute pancreatitis. |
| Biological Activity | L-Arginine HCl (L-Arg) is a nitrogen donor for nitric oxide synthesis, acting as an effective vasodilator, often deficient in sickle cell anemia [1-2]. |
| In Vitro | Supplementation of L-Arginine (0.3 mm, 30 분) increases NO concentration twofold in bovine aortic endothelial cells with an LDL concentration of 60-130 mg cholesterol/dL. In conditions with low LDL, L-Arginine (0.3 mm, 30 분) does not increase NO peak concentration or O2- levels. Pre-treatment with L-Arginine reduces O2- production by 50% when incubated with n-LDL above 40mg cholesterol/dL and completely inhibits O2- production from oxidized LDL doses [1]. |
| In Vivo | In rabbit limbs with ischemia/reperfusion injury, L-Arginine (4 mg/kg/min for 1 시간) reduces superoxide production by cNOS, increases NO accumulation, prevents microvascular contraction, and significantly reduces muscle edema [2]. |
| 참고자료 | [1]. Vergnani L, 외. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation. 2000 Mar 21;101(11):1261-6. [2]. Huk I, 외. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 1997 Jul 15;96(2):667-75. |
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