Solarbio L-Arginine (hydrochloride) CAS 1119-34-2 Size 100mg

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Description

Specification

  • 100mg Powder
Product Information
CAS1119-34-2
Chinese NameL-精氨酸盐酸盐
English NameL-Arginine Hydrochloride
Synonyms
  • (S)-(+)-Arginine hydrochloride
  • N-Carbobenzoxy-D-leucine
  • N-Carbobenzyloxy-D-leucine
  • NSC523826;
Molecular FormulaC6H14N4O2·HCl
Molecular Weight210.66
Specifications10mM*1mL in Water; 100mg
SolubilitySoluble in Water ≥10mg/mL
Storage ConditionsPowder: 2-8℃, 2 years; In solution: -20℃, 6 months; -80℃, 1 year
PurityHPLC≥98%
AppearanceWhite to off-white Solid
UnitBottle
ECEINECS 214-275-1
MDLMFCD00064550
SMILESNC@@HC(O)=O.[H]Cl
InChIKeyKWTQSFXGGICVPE-WCCKRBBISA-N
InChIInChI=1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
PubChem CID66250
TargetsOthers
PathwayOthers
Background InformationReported to be an effective vasodilator used to induce experimental acute pancreatitis.
Biological ActivityL-Arginine HCl (L-Arg) is a nitrogen donor for nitric oxide synthesis, acting as an effective vasodilator, often deficient in sickle cell anemia [1-2].
In VitroSupplementation of L-Arginine (0.3 mM, 30 minutes) increases NO concentration twofold in bovine aortic endothelial cells with an LDL concentration of 60-130 mg cholesterol/dL. In conditions with low LDL, L-Arginine (0.3 mM, 30 minutes) does not increase NO peak concentration or O2- levels. Pre-treatment with L-Arginine reduces O2- production by 50% when incubated with n-LDL above 40mg cholesterol/dL and completely inhibits O2- production from oxidized LDL doses [1].
In VivoIn rabbit limbs with ischemia/reperfusion injury, L-Arginine (4 mg/kg/min for 1 hour) reduces superoxide production by cNOS, increases NO accumulation, prevents microvascular contraction, and significantly reduces muscle edema [2].
References[1]. Vergnani L, et al. Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of L-arginine availability. Circulation. 2000 Mar 21;101(11):1261-6.

[2]. Huk I, et al. L-arginine treatment alters the kinetics of nitric oxide and superoxide release and reduces ischemia/reperfusion injury in skeletal muscle. Circulation. 1997 Jul 15;96(2):667-75.

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